Functional characterization of a unique liver gene promoter.
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چکیده
منابع مشابه
Functional characterization of a unique liver gene promoter.
Human phenylalanine hydroxylase (PAH) is specifically expressed in the liver to convert L-phenylalanine to L-tyrosine. Deficiency of the PAH enzyme causes classic phenylketonuria, a common genetic disorder. The human PAH gene has a TATA-less promoter with multiple transcriptional initiation sites. A 9-kilobase DNA fragment 5'-flanking to the human PAH gene is sufficient to confer tissue- and de...
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Fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11), an important gluconeogenic enzyme, catalyses the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate and P(i). Enzyme activity is mainly regulated by the allosteric inhibitors fructose 2, 6-bisphosphate and AMP. Although some observations about hormonal regulation of the enzyme have been published, the FBPase promoter has not been ...
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background: peroxisome proliferator activated receptor gamma (pparγ), a member of nuclear receptor superfamily, comprises two isoforms in mouse. these two isoforms are encoded by different mrnas, which are arisen by alternative promoter usage. there are two promoter regions upstream of pparγ gene. a 3 kb fragment, containing several transcription factor binding sites, acts as pparγ1 promoter re...
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FUNCTIONAL AND STRUCTU CHACTERIZATION OF A HU H4 HISTONE GENE PROMOTER Kenneth Lynn wright November 1990 Thesis Advisor: Janet L. Stein Department: Cell Biology Expression of the cell cycle dependent FOI08 human H4 histone gene is regulated at both the transcriptional and post-transcriptional levels. We have investigated the promoter elements mediating the transcriptional aspects of its regulat...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)37087-4